Cellular Metabolic Maintenance
Gene co-expression module in Innate lymphoid cells
| Category | Metabolism |
|---|---|
| Genes | 22 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
SHMT2 (serine/one-carbon metabolism), GPI (glycolysis/gluconeogenesis), UQCRC1 (mitochondrial complex III), PYCR2 (proline biosynthesis), DHPS (hypusine synthesis for eIF5A), MFF (mitochondrial fission), ADIPOR1 (fatty acid oxidation), CYB5R3 (electron transfer) collectively represent a broad cellular metabolic program. The module is enriched in ILC1s and reflects housekeeping metabolic activity. CSNK2B and PPP2R1A add signaling context. The mix of mitochondrial, glycolytic, and biosynthetic genes suggests a general metabolic maintenance program.
Genes
ADIPOR1, APH1A, ARF5, BCAP31, CLIC1, CSNK2B, CYB5R3, DHPS, ERGIC3, GPI, GRSF1, MFF, OTUB1, PCBP2, POLR2E, PPP2R1A, PTDSS1, PYCR2, SHMT2, SPG21, UQCRC1, VKORC1
Most correlated modules
- ILC Transcription Factor Program · correlation 0.94
- JAK-STAT Cytokine Signaling · correlation 0.86
- NK Activating Receptors · correlation 0.85
- Interferon-Stimulated Genes · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.