FLT3LG — Fms related receptor tyrosine kinase 3 ligand
FLT3LG belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FLT3LG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Naïve T Cell State T cell maturation | ARL14EP, CCR2, CD27, CD28, CD40LG, CD82, CNN2, CPNE2 +19 more | |
| Innate lymphoid cells | NK Activating Receptors Cytotoxicity | CAT, CRACDL, ELAPOR1, KLRK1, KRTCAP2, LTA4H, MFSD10, MLLT3 +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytotoxic Lymphocyte Program cytotoxicity | ANXA11, CDKN2D, CYB5A, EMP3, ETHE1, GLIPR2, LDHB, LTB +9 more |
About the gene
| Chromosome | 19: 49474207-49486231 |
|---|---|
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins |
| Molecular function | Cytokine |
Function
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Required for the development of B cells, and dendritic cells (DCs)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.