RAPGEF6 — Rap guanine nucleotide exchange factor 6
RAPGEF6 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAPGEF6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Post-transcriptional regulation RNA processing | BCL11B, CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B +21 more | View in SCUBA |
| Gamma-delta T cells | AHR/NF-κB Survival Immune regulation | ABCC1, AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, BIRC3 +24 more | |
| Innate lymphoid cells | NK Activating Receptors Cytotoxicity | CAT, CRACDL, ELAPOR1, FLT3LG, KLRK1, KRTCAP2, LTA4H, MFSD10 +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | TGF-β Immune Regulation Immune regulation | ADAM12, AFF1, AKAP9, FNBP4, IKZF3, INPP4A, MAN1A1, NSD3 +8 more |
About the gene
| Synonyms | PDZ-GEF2, PDZGEF2, RA-GEF-2 |
|---|---|
| Chromosome | 5: 131423921-131635231 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.