Pre-mRNA Splicing
Gene co-expression module in Lymphatic endothelial
| Category | RNA processing & translation |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes DDX17 (DEAD-box RNA helicase involved in pre-mRNA splicing and miRNA processing), ARGLU1 (splicing regulator interacting with SR proteins), LUC7L3 (U1 snRNP-associated splicing factor), PNISR (splicing regulator), and ZRANB2 (zinc-finger RNA-binding splicing factor) define a pre-mRNA splicing program. N4BP2L2 has RNA processing functions. BPTF and ATRX are chromatin remodelers that couple transcription to co-transcriptional splicing. SYNE2 (neighbor to M13's SYNE1) and DST/TACC1 are peripheral cytoskeletal members. The core program is RNA splicing regulation.
Genes
ARGLU1, ATRX, BPTF, DDX17, DST, LUC7L3, N4BP2L2, NKTR, PNISR, PTPRE, SYNE2, TACC1, UACA, VPS13C, ZRANB2
Most correlated modules
- Actomyosin Contractility · correlation 0.83
- Endosomal Vesicle Trafficking · correlation 0.82
- Lymphatic Specification · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.