SCUBA

TACC1 — Transforming acidic coiled-coil containing protein 1

TACC1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TACC1's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsActin cytoskeleton remodeling
Cytoskeletal
ACTR2, BASP1, CAPZA1, CDV3, EIF3A, FAM107B, GRB2, HCLS1 +9 moreView in SCUBA
CD4⁺ T cellsMembrane Trafficking
Protein processing & ER
B4GALT1, BTF3L4, CELF1, CLTC, CSNK1G3, CTBS, DERL2, DYNC1LI2 +23 moreView in SCUBA
EndothelialCaveolae-mediated Transcytosis
Metabolite transfer
ADIPOR2, CAV1, CAV2, CCDC85A, CD320, EEPD1, EMP2, ENAH +19 moreView in SCUBA
Gamma-delta T cellsHypoxia Stress Response
Stress
ARIH2, BNIP2, C9orf78, CHD4, FBXO7, HIF1A, HNRNPH1, JADE1 +16 more
Lymphatic endothelialPre-mRNA Splicing
RNA processing & translation
ARGLU1, ATRX, BPTF, DDX17, DST, LUC7L3, N4BP2L2, NKTR +6 moreView in SCUBA
MacrophagesGeneral Cellular Maintenance
Housekeeping
ABHD13, AKT2, AMD1, C1GALT1, DCUN1D1, FBXL3, FMR1, GAK +13 moreView in SCUBA
Mucosal-associated invariant T cellCytoskeletal Organization
Cytoskeletal
ARAP2, CHD8, CTNNB1, DYNC1H1, EP400, NFATC2, RASSF2, RNF4 +4 more
Smooth muscle cellsCytoskeletal trafficking kinases
Cytoskeletal
AMIGO2, CACNA1C, CDC14B, DHRS3, IQSEC1, KIF1C, LYSMD2, MAPKAPK3 +6 moreView in SCUBA

About the gene

Chromosome8: 38728186-38853028
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins
Molecular functionActivator
Biological processCell cycle, Cell division

Function

Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors. Likely involved in the processes that promote cell division prior to the formation of differentiated tissues

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.