UACA — Uveal autoantigen with coiled-coil domains and ankyrin repeats
UACA belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UACA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Angiogenic Activation Inflammation | ALPL, APOL4, ASAP2, CALM1, COMMD2, FAT4, PDGFB, PLS3 +4 more | View in SCUBA |
| Enterocytes | Junctional Hippo/TGF-beta signaling Migration & adhesion | AFDN, BACH1, CCNL1, DAPK2, DST, PELI2, SMAD3, WWC1 | View in SCUBA |
| Lymphatic endothelial | Pre-mRNA Splicing RNA processing & translation | ARGLU1, ATRX, BPTF, DDX17, DST, LUC7L3, N4BP2L2, NKTR +6 more | View in SCUBA |
| Monocytes | M2 Macrophage Polarization Innate immunity | AHNAK, CRTAP, F13A1, GLDN, GSN, IDH1, IL13RA1, LDHB +7 more | View in SCUBA |
| Pericytes | TGF-β Cytoskeletal Remodeling Cytoskeletal | ARHGEF12, ASAP1, GRK5, LRRC32, MYH9, RAPGEF2, RFTN1, SERPINH1 +2 more | View in SCUBA |
About the gene
| Synonyms | FLJ10128, KIAA1561 |
|---|---|
| Chromosome | 15: 70654554-70763558 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.