Actomyosin Contractility
Gene co-expression module in Lymphatic endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
ROCK1 and ROCK2 (Rho-associated kinases) are central regulators of actomyosin contractility. PPP1R12A (MYPT1) is the myosin phosphatase targeting subunit directly downstream of ROCK. MAP4 stabilizes microtubules. SYNE1 (nesprin-1) links the nucleus to the actin cytoskeleton via the LINC complex. AFAP1L1 is an actin filament-associated protein. COBLL1 has cytoskeletal roles. SEMA3D signals through cytoskeletal collapse pathways. This module represents a coherent actomyosin contractility and cytoskeletal organization program. Neighbor M34 shares SYNE2, reinforcing nuclear-cytoskeletal coupling across both modules.
Genes
AFAP1L1, C1orf21, COBLL1, EEA1, GNB1, MAP4, OSBPL8, PPP1R12A, ROCK1, ROCK2, SCAF11, SEMA3D, SMARCA2, SYNE1, ZFHX3
Most correlated modules
- Chromatin Remodeling · correlation 0.90
- Endosomal Vesicle Trafficking · correlation 0.89
- ZEB1-driven EMT · correlation 0.85
- Focal Adhesion Migration · correlation 0.85
- Chromatin Remodeling · correlation 0.84
- Lymphatic EC Identity · correlation 0.83
- Pre-mRNA Splicing · correlation 0.83
- ECM-driven Migration · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.