Chromatin Remodeling
Gene co-expression module in Lymphatic endothelial
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by chromatin remodeling and epigenetic regulators: GATAD2A (NuRD complex), CHD1 (chromodomain helicase), ASXL1 and RYBP (Polycomb-associated), KMT2E (H3K4 methyltransferase), MED13 (Mediator complex), NUP153 (nuclear pore/chromatin organization), and TOP1 (DNA topoisomerase). Together these define a chromatin remodeling and epigenetic regulation program. PFKFB3 is a metabolic outlier but may be co-regulated in transcriptionally active states. Uniform expression across subsets is consistent with a broadly active chromatin regulatory program in lymphatic endothelial cells.
Genes
ASXL1, CHD1, GATAD2A, KMT2E, LONRF3, MED13, NUP153, PFKFB3, RYBP, TOP1
Most correlated modules
- NF-κB Innate Signaling · correlation 0.87
- DNA Damage Apoptosis · correlation 0.87
- ZEB1-driven EMT · correlation 0.82
- MAPK-ERK Signaling · correlation 0.79
- TBK1-JAK Immune Signaling · correlation 0.74
- Basement Membrane ECM · correlation 0.72
- NF-κB Inflammatory Activation · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.