TBK1-JAK Immune Signaling
Gene co-expression module in Lymphatic endothelial
| Category | Inflammation |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
TBK1 (innate immune kinase activating IRF3/NF-κB), JAK1 (JAK-STAT cytokine signaling), ZC3H12C (MCPIP3, mRNA decay regulator of inflammatory transcripts), MAP4K4 (stress/inflammatory MAPK cascade), and ADAM17 (ectodomain shedding of cytokine receptors/ligands) define an innate immune/cytokine signaling program. AGO2 adds post-transcriptional regulation of immune gene expression. NAMPT (NAD biosynthesis, inflammatory mediator) and FNIP2 (mTOR/AMPK, metabolic immune regulation) are supporting members. This module is a topological neighbor of M19 (NF-κB), representing the TBK1-JAK1 downstream signaling arm.
Genes
ADAM17, AGO2, ELL2, FNIP2, IQGAP1, JAK1, MAP4K4, NAMPT, NPC1, SLC4A7, SNX9, SPAG9, TBK1, UBE2D3, ZC3H12C
Most correlated modules
- NF-κB Innate Signaling · correlation 0.91
- Actin Cytoskeletal Dynamics · correlation 0.89
- Basement Membrane ECM · correlation 0.88
- NRF2 Oxidative Stress · correlation 0.86
- DNA Damage Apoptosis · correlation 0.79
- Stress Kinase Signaling · correlation 0.75
- Chromatin Remodeling · correlation 0.74
- NF-κB Inflammatory Activation · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.