NF-κB Innate Signaling
Gene co-expression module in Lymphatic endothelial
| Category | Inflammation |
|---|---|
| Genes | 20 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
NFKB1 (NF-κB p50) and HIVEP2/HIVEP1 (NF-κB-binding zinc finger TFs) are top hubs. IRAK2 (IL-1R/TLR pathway kinase), PELI1 (E3 ligase in TLR/NF-κB), TAB2 (TAK1 adaptor activating NF-κB), TRAF3 (TRAF family innate immune adaptor), and BACH1 (inflammatory/oxidative stress repressor) form a coherent NF-κB/innate immune signaling module. All genes show core membership and uniform expression. The highest delta_inflammation_CD in the batch (1.541, n.s.) is consistent. Neighbor M7 contains TBK1 and JAK1, representing a complementary innate immune signaling arm.
Genes
AKAP13, B4GALT5, BACH1, CHD2, CNST, DENND5A, HIVEP1, HIVEP2, IRAK2, LRRFIP2, MEF2A, NFKB1, NRIP1, PALM2AKAP2, PELI1, RLF, SAMD4A, TAB2, TRAF3, UBE2H
Most correlated modules
- TBK1-JAK Immune Signaling · correlation 0.91
- ZEB1-driven EMT · correlation 0.88
- Chromatin Remodeling · correlation 0.87
- Basement Membrane ECM · correlation 0.85
- DNA Damage Apoptosis · correlation 0.82
- MAPK-ERK Signaling · correlation 0.82
- ECM-driven Migration · correlation 0.79
- NRF2 Oxidative Stress · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.