NF-κB Inflammatory Activation
Gene co-expression module in Lymphatic endothelial
| Category | Inflammation |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
KDM6B (JMJD3, H3K27me3 demethylase induced by NF-κB/inflammation), NFKBIZ (IκBζ, atypical NF-κB activator), IRF1 (interferon/inflammatory TF), BCL3 (NF-κB coactivator), MAP3K8 (COT1/TPL2, NF-κB pathway kinase), CD83 (activation-induced surface marker), and HIF1A (hypoxia-NF-κB crosstalk) define a strong NF-κB/inflammatory activation program with epigenetic remodeling. The highest delta_inflammation_CD (2.168) in the batch supports this. As a neighbor to M67 (NF-κB negative feedback), M65 represents the activation arm of the same NF-κB axis.
Genes
BCL3, CD83, HIF1A, INSIG1, IPO7, IRF1, KDM6B, MAP3K8, NFKBIZ, PPP1R15B
Most correlated modules
- DNA Damage Apoptosis · correlation 0.88
- NF-κB Negative Feedback · correlation 0.88
- DNA Damage Autophagy · correlation 0.85
- Stress Granule Assembly · correlation 0.82
- Integrated Stress Response · correlation 0.79
- Notch TGF-β Endothelial · correlation 0.79
- Stress Kinase Signaling · correlation 0.78
- NF-κB Autophagy Regulation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.