Basement Membrane ECM
Gene co-expression module in Lymphatic endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
COL4A1 and COL4A2 (collagen IV, major basement membrane components), PXDN (peroxidasin, crosslinks collagen IV in basement membrane), ITGAV (integrin αV, ECM receptor), WWTR1/TAZ (YAP/TAZ mechanosensing transcriptional co-activator downstream of ECM stiffness), and RAI14 (cytoskeletal scaffold at cell-ECM junctions) define a basement membrane organization and mechanosensing program. RB1CC1 (FIP200/autophagy) and BRD4 (transcriptional regulation) are supporting members. GOLGA4 (Golgi) and PITPNB (lipid transfer) may support collagen secretion. This program is highly relevant to lymphatic vessel wall integrity and ECM remodeling.
Genes
BRD4, COL4A1, COL4A2, GOLGA4, ITGAV, PITPNB, PXDN, RAI14, RB1CC1, SRSF4, WNK1, WWTR1, YES1
Most correlated modules
- TBK1-JAK Immune Signaling · correlation 0.88
- NF-κB Innate Signaling · correlation 0.85
- ZEB1-driven EMT · correlation 0.85
- Actin Cytoskeletal Dynamics · correlation 0.78
- ECM-driven Migration · correlation 0.77
- NRF2 Oxidative Stress · correlation 0.75
- Chromatin Remodeling · correlation 0.72
- DNA Damage Apoptosis · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.