DNA Damage Apoptosis
Gene co-expression module in Lymphatic endothelial
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub TP53BP2 (p53-binding protein, DNA damage/apoptosis scaffold), BAZ1A (chromatin remodeling at DNA damage sites), OTUD4 (deubiquitinase involved in DNA damage response), TNFRSF10B (TRAIL-R2, extrinsic apoptosis receptor), USP12 (deubiquitinase), and MAPK6 (atypical MAPK with roles in survival/apoptosis) collectively define a DNA damage response and apoptosis signaling program. UGCG (ceramide glycosylation, apoptosis-linked lipid) and AZIN1 (polyamine pathway, cell survival) are consistent supporting members.
Genes
AZIN1, BAZ1A, HNRNPC, IVNS1ABP, MAPK6, OTUD4, PHLDB2, SPEN, STX3, TNFRSF10B, TP53BP2, UGCG, USP12
Most correlated modules
- NF-κB Inflammatory Activation · correlation 0.88
- Chromatin Remodeling · correlation 0.87
- Stress Kinase Signaling · correlation 0.83
- NF-κB Innate Signaling · correlation 0.82
- TBK1-JAK Immune Signaling · correlation 0.79
- DNA Damage Autophagy · correlation 0.78
- NF-κB Negative Feedback · correlation 0.76
- NRF2 Oxidative Stress · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.