Oxidative Phosphorylation
Gene co-expression module in Lymphatic endothelial
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 14 genes have a known function matching the annotation |
Why this annotation
Module is dominated by ATP synthase subunits (ATP5PD, ATP5PF, ATP5PO, ATP5MC3, ATP5MC1, ATP5F1C, ATP5MF, ATP5IF1) spanning both F0 and F1 domains of Complex V, plus NADH dehydrogenase subunits (NDUFS7, NDUFB8) from Complex I, UQCR11 from Complex III, and MRPL57 (mitochondrial ribosomal protein supporting mitochondrial translation). All genes are core members with uniform expression, consistent with a housekeeping oxidative phosphorylation program. Neighbor M52 contains the complementary set of ATP synthase and respiratory chain subunits, confirming these are two partitions of the same OxPhos network.
Genes
ATP5F1C, ATP5IF1, ATP5MC1, ATP5MC3, ATP5MF, ATP5PD, ATP5PF, ATP5PO, COPS9, ELOB, MRPL57, NDUFB8, NDUFS7, UQCR11
Most correlated modules
- Mitochondrial OxPhos Complex · correlation 0.95
- Housekeeping Mixed · correlation 0.94
- Fatty Acid Oxidation · correlation 0.93
- Lymphatic EC Identity · correlation 0.91
- Metabolic Housekeeping · correlation 0.91
- Caveolae Cytoskeletal · correlation 0.90
- Mitochondrial OxPhos Complex · correlation 0.90
- Oxidative Phosphorylation · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.