Caveolae Cytoskeletal
Gene co-expression module in Lymphatic endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
CAVIN1 (PTRF) is a caveolae-associated protein critical for caveolae formation and lipid metabolism. DYNLL1 is a dynein light chain involved in cytoskeletal transport. TPM4 is tropomyosin 4 (actin cytoskeleton). MARCKSL1 is a membrane/actin-associated protein. CALM1 is calmodulin (calcium signaling/cytoskeletal). CRIP2 is a LIM domain protein involved in cytoskeletal organization. TIMP2 is a matrix metalloproteinase inhibitor. CTSZ is cathepsin Z (lysosomal protease). HOXD8/HOXD9 are transcription factors. SELENOW is a selenoprotein with antioxidant function. EPHX1 is epoxide hydrolase. LRPAP1 is a chaperone for LRP receptors. GSTK1 is a glutathione transferase. The module combines cytoskeletal (CAVIN1, DYNLL1, TPM4, MARCKSL1, CALM1, CRIP2) and ECM remodeling (TIMP2, CTSZ) programs, with CAVIN1 as a prominent hub suggesting caveolae-associated cytoskeletal organization.
Genes
CALM1, CAVIN1, CRIP2, CTSZ, DYNLL1, EPHX1, GSTK1, HOXD8, HOXD9, LRPAP1, MARCKSL1, PEPD, REX1BD, SELENOW, TIMP2, TPM4
Most correlated modules
- Lymphatic EC Identity · correlation 0.96
- Oxidative Stress Protection · correlation 0.94
- Fatty Acid Oxidation · correlation 0.93
- Metabolic Housekeeping · correlation 0.91
- Mitochondrial OxPhos Complex · correlation 0.91
- Oxidative Phosphorylation · correlation 0.90
- ECM Remodeling TGFb · correlation 0.88
- Housekeeping Mixed · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.