Housekeeping Mixed
Gene co-expression module in Lymphatic endothelial
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
NDUFB11 is a Complex I subunit. PRDX5 is a mitochondrial peroxiredoxin. SSR4 is a signal sequence receptor subunit (ER translocon). GUK1 is guanylate kinase (nucleotide metabolism). VPS28 is an ESCRT-I component. LAMTOR4 is a lysosomal mTORC1 regulator. ZNHIT1 is a chromatin remodeling factor. RNASEH2C is involved in DNA replication/repair. NEDD8 is a ubiquitin-like modifier. The module is heterogeneous with no single dominant program; however, the presence of NDUFB11 and PRDX5 links it to the OxPhos neighborhood, while SSR4 and NEDD8 suggest protein processing. The module likely represents a housekeeping admixture co-expressed with the OxPhos neighborhood.
Genes
GUK1, LAMTOR4, NDUFB11, NEDD8, PRDX5, RNASEH2C, SSR4, VPS28, ZNHIT1
Most correlated modules
- Mitochondrial OxPhos Complex · correlation 0.96
- Mitochondrial OxPhos Complex · correlation 0.94
- Fatty Acid Oxidation · correlation 0.94
- Mitochondrial OxPhos Complex · correlation 0.94
- Oxidative Stress Response · correlation 0.94
- Oxidative Phosphorylation · correlation 0.94
- Oxidative Phosphorylation · correlation 0.90
- Metabolic Housekeeping · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.