SCUBA

CLTA — Clathrin light chain A

CLTA belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CLTA's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsmRNA Splicing
RNA processing
FKBP1A, HNRNPC, HNRNPK, RAC1, SLC25A3, SLC25A5, SRSF9, TKT +1 moreView in SCUBA
CD4⁺ T cellsOxPhos & proteasome
Mitochondrial & OxPhos
CCDC167, COX17, COX5A, DBI, FKBP1A, FMNL1, GALM, MRPL41 +10 moreView in SCUBA
CD8⁺ T cellsProteasome Degradation
Housekeeping
ARPP19, GNG5, HSBP1, NDUFB4, POLR2J, POLR2K, PSMB2, PSMB3 +2 moreView in SCUBA
FibroblastsGeneral Housekeeping
Housekeeping
ATP6V0E1, C19orf53, EDF1, ERH, NEDD8, PARK7, SEC11A, SNU13 +4 moreView in SCUBA
Goblet cellsSR Splicing Factors
RNA processing & translation
GLRX5, MLEC, NDUFAB1, PPP1R14B, SRSF2, SRSF9, TRIR, UQCRFS1 +1 moreView in SCUBA
Innate lymphoid cellsProteasome & TCA
Protein processing & ER
ACP1, ARPC5L, CAPZA1, COPS9, HDAC1, MDH2, NDUFA1, NUDT16L1 +5 moreView in SCUBA
Lymphatic endothelial20S Proteasome Core
Protein processing & ER
ATP6V0E1, DBI, ERH, NOP10, PRDX1, PSMA7, PSMB1, PSMB2 +4 moreView in SCUBA
MacrophagesProtein Homeostasis Mixed
Housekeeping
ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, COPS9 +33 moreView in SCUBA
Smooth muscle cellsTranslocon & Proteostasis
Housekeeping
ATP6V0E1, EIF3F, NOP10, NPC2, PSMA1, SEC61G, ST13, SUB1 +2 moreView in SCUBA

About the gene

SynonymsLca
Chromosome9: 36190856-36304781
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins, Transporters
Biological processCell cycle, Cell division, Mitosis

Function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.