Proteasome Assembly
Gene co-expression module in Lymphatic endothelial
| Category | Protein processing & ER |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes: PSME2 (proteasome activator PA28 subunit, immunoproteasome), PDCD5 (programmed cell death 5, apoptosis), MRPL14 (mitochondrial ribosomal protein), GSTO1 (glutathione S-transferase omega, oxidative stress/detox), CSTB (cystatin B, cysteine protease inhibitor), POMP (proteasome maturation protein), ARPC2 (Arp2/3 complex, actin branching), SNRPG (spliceosome), PSMD7 (26S proteasome non-ATPase subunit), SLC39A1 (zinc transporter), ZNF706 (zinc finger), PRELID1 (mitochondrial lipid transfer), VDAC1 (mitochondrial outer membrane channel), DEGS1 (sphingolipid desaturase). Multiple proteasome genes (PSME2, POMP, PSMD7) alongside PDCD5 and CSTB suggest proteasome-mediated protein degradation and apoptosis regulation. GSTO1 adds oxidative stress context. Neighbor context: directly neighbors M55 (proteasome subunits PSMB1-6) and M56 (PSME1, PSMB8, HLA), forming a proteasome/immunoproteasome cluster. This module represents proteasome assembly and maturation.
Genes
ARPC2, CSTB, DEGS1, GSTO1, MRPL14, PDCD5, POMP, PRELID1, PSMD7, PSME2, SLC39A1, SNRPG, VDAC1, ZNF706
Most correlated modules
- Oxidative Stress Response · correlation 0.90
- 20S Proteasome Core · correlation 0.89
- MHC-I Antigen Presentation · correlation 0.86
- Cytoskeletal Housekeeping · correlation 0.81
- Hypoxia HIF Response · correlation 0.81
- Actomyosin Cytoskeleton · correlation 0.80
- mRNA Translation Regulation · correlation 0.80
- RNA Protein Homeostasis · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.