mRNA Translation Regulation
Gene co-expression module in Lymphatic endothelial
| Category | RNA processing & translation |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes YBX1 (mRNA binding/translation regulation), BTF3 (nascent polypeptide-associated complex), EEF1B2 (translation elongation factor), NPM1 (ribosome biogenesis), and BZW1 (translation initiation factor) all converge on mRNA translation and RNA processing. GAPDH, YWHAE, SDCBP, and CLIC1 are broadly expressed housekeeping genes. Uniform expression across all subsets, high detection rate (75.8%), and no disease association confirm a constitutive housekeeping/translation program. Neighbor modules M62 and M53 also show housekeeping signatures, supporting this interpretation.
Genes
BTF3, BZW1, CLIC1, EEF1B2, GAPDH, NPM1, SDCBP, YBX1, YWHAE
Most correlated modules
- Translation Elongation · correlation 0.95
- RNA Protein Homeostasis · correlation 0.89
- Actomyosin Cytoskeleton · correlation 0.88
- Oxidative Stress Response · correlation 0.88
- MHC-I Antigen Presentation · correlation 0.85
- Proteasome Assembly · correlation 0.80
- 20S Proteasome Core · correlation 0.79
- Protein Quality Control · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.