TRAM1 — Translocation associated membrane protein 1
TRAM1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRAM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | ER-Golgi Trafficking Protein processing & ER | ATL3, DIAPH2, ECE1, EID1, GOLIM4, KTN1, MAGT1, PGK1 +4 more | View in SCUBA |
| Fibroblasts | ER Protein Folding Housekeeping | AHCYL1, CANX, CSNK1A1, HNRNPK, HSP90B1, JAK1, KDELR1, KTN1 +10 more | View in SCUBA |
| Lymphatic endothelial | ER-Lysosomal Processing Protein processing & ER | BCAP31, CTSD, DHRS7, EHD2, GRN, LAMP1, OS9, PSAP +2 more | View in SCUBA |
| Macrophages | Autophagy Vesicular Trafficking Vesicular traficking | ACTR2, AHCYL1, ALKBH5, BECN1, BICD2, CAP1, CAPRIN1, COLGALT1 +32 more | View in SCUBA |
| Pericytes | Immunoproteasome Induction Inflammatory | CANX, GRN, LY6E, NUCB1, PGK1, PSAP, PSMB8, PSMB9 +3 more | View in SCUBA |
About the gene
| Synonyms | TRAM, TRAMP |
|---|---|
| Chromosome | 8: 70573218-70608416 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins, Transporters |
| Biological process | Host-virus interaction, Protein transport, Translocation, Transport, Unfolded protein response |
Function
Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel. Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER. May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport. Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane. Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane. Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome. (Microbial infection) In case of cytomegalovirus infection, participates in US2- and US11-mediated ER-to-cytosol retrotranslocation and subsequent degradation of major histocompatibility complex (MHC) class I heavy chains, thereby decreasing the immune detection by cytotoxic T-cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.