Antigen Presentation IFN
Gene co-expression module in Lymphatic endothelial
| Category | Inflammation |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
TAPBP (tapasin) and HLA-F are directly involved in MHC class I antigen loading and presentation. PARP14 is an IFN-gamma-induced ADP-ribosyltransferase. ADAR mediates adenosine-to-inosine RNA editing as part of innate immune sensing. TRIM56 is an E3 ubiquitin ligase that activates innate antiviral signaling. SCARB2 is a lysosomal membrane receptor. TNFRSF4 (OX40) is a T-cell costimulatory receptor, possibly reflecting lymphatic-immune cell crosstalk. The module is significantly upregulated in CD inflammation (delta=0.670, sig.), consistent with IFN-driven antigen presentation induction in inflamed intestinal lymphatics.
Genes
ADAR, GPRC5B, HLA-F, KTN1, PARP14, PTTG1IP, SCARB2, TAPBP, TMEM123, TNFRSF4, TRIM56
Most correlated modules
- Glycolytic Housekeeping · correlation 0.83
- Proteasome Assembly · correlation 0.59
- Genotoxic Innate Inflammation · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.