TAPBP — TAP binding protein

TAPBP belongs to a gene co-expression module in 15 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TAPBP's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	MHC-II antigen presentation B cell maturation	ARID5A, CD52, CD74, CD79A, CTSS, CYBA, HLA-DPA1, HLA-DPB1 +9 more	View in SCUBA
CD4⁺ T cells	Cell motility/adhesion migration & adhesion	ANXA2, CCDC107, CYBA, FAM50A, GLIPR2, GRAP2, GYG1, ITM2B +14 more	View in SCUBA
Endothelial	Complement Innate Immune Inflammation	C1R, C1S, CD47, CNDP2, COL5A2, CTSS, GRINA, GSDMD +9 more	View in SCUBA
Enterocytes	IFN-gamma response Inflammation	APOL6, BIRC3, GBP1, GBP2, IRF1, NUB1, PARP14, PARP9 +2 more	View in SCUBA
Fibroblasts	NF-κB Inflammatory Activation Inflammatory	BIRC3, CD40, CTSS, DRAM1, HAPLN3, IL15RA, IL32, LAP3 +5 more	View in SCUBA
Gamma-delta T cells	mRNA Splicing Processing RNA processing & translation	ARHGEF1, BECN1, CCNI, DENND4B, EID1, HNRNPA0, HNRNPDL, KLHDC4 +18 more
Glial cells	Type I/II Interferon Response Inflammation	GBP2, HLA-F, IFI6, IFIT3, ISG15, LY6E, PSMB8, PSMB9 +6 more	View in SCUBA
Goblet cells	MHC Class I Antigen Presentation Immune function	APOL1, APOL6, B2M, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F +4 more	View in SCUBA
Innate lymphoid cells	Antigen Processing MHC-I Immune regulation	CMTM6, GUK1, IL2RB, IL4R, MYL12A, PAXX, PSMA5, PSMB8 +8 more	View in SCUBA
Lymphatic endothelial	Antigen Presentation IFN Inflammation	ADAR, GPRC5B, HLA-F, KTN1, PARP14, PTTG1IP, SCARB2, TMEM123 +2 more	View in SCUBA
Macrophages	ER Protein Quality Control Lysosomal & pahgocytosis	ACP2, C5orf15, CLN5, CS, CTBP1, ERGIC3, FUT11, GANAB +18 more	View in SCUBA
Mucosal-associated invariant T cell	ER Protein Glycosylation Protein processing & ER	ANAPC5, HNRNPM, LMAN2, PDAP1, PKM, PRKCSH, RHOA, RPN1 +3 more
Neutrophils	Bacterial Phagocytosis Program Phagocytosis	CASP4, CLEC7A, CSF2RB, CSF3R, CYTH4, FCGR2A, LY96, SLC11A1 +1 more
Pericytes	NF-κB Inflammatory Activation Inflammatory	CTSS, EFHD2, HIF1A, IL32, LAP3, OSMR, TMEM165	View in SCUBA
Smooth muscle cells	IFN-gamma/NF-kB Response Inflammation	ATP6V0B, CCDC71L, CFLAR, CHI3L2, EVA1B, GBP1, GBP2, HSPA8 +11 more	View in SCUBA

About the gene

Synonyms	TAPA
Chromosome	6: 33299694-33314284
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Function

Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.