TRIM56 — Tripartite motif containing 56
TRIM56 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRIM56's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Splicing RNA processing & translation | ACTB, ACTG1, ACTL6A, ACTR3, AK2, BRD8, CASP2, CCDC14 +13 more | |
| Innate lymphoid cells | IFN-gamma Response Inflammation | APOL6, B3GALT5, DST, ELK3, GBP2, GBP4, GBP5, GOLGA8A +16 more | View in SCUBA |
| Lymphatic endothelial | Antigen Presentation IFN Inflammation | ADAR, GPRC5B, HLA-F, KTN1, PARP14, PTTG1IP, SCARB2, TAPBP +2 more | View in SCUBA |
| Macrophages | Golgi-Endosome Trafficking Vesicular traficking | ACSL4, ADPGK, ARRDC3, ATXN7L3B, CLN8, DDB1, DNAJC2, ETS2 +26 more | View in SCUBA |
| Mucosal-associated invariant T cell | Vesicle Membrane Trafficking Housekeeping | ACSL5, AP2B1, APOBR, CAPRIN1, CAPZA1, DDX23, G3BP1, IARS1 +6 more | |
| Pericytes | TGF-beta Negative Feedback Inflammatory | CTNND1, DAZAP2, EMP1, KAT6A, KBTBD2, KLF7, MLKL, RCAN1 +6 more | View in SCUBA |
About the gene
| Synonyms | RNF109 |
|---|---|
| Chromosome | 7: 101085481-101097967 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Antiviral defense, Immunity, Innate immunity, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1. In response to pathogen- and host- derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation. Promotes also TNFalpha-induced NF-kappa-B signaling by mediating 'Lys-63'-linked ubiquitination TAK1, leading to enhanced interaction between TAK1 and CHUK/IKKalpha. Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus. Acts as a restriction factor of Zika virus through direct interaction with the viral RNA via its C-terminal region.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.