Genotoxic Innate Inflammation
Gene co-expression module in Lymphatic endothelial
| Category | Inflammation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
NBN (nibrin/NBS1) and E2F7 are DNA damage response genes; NBN is part of the MRN complex and E2F7 is induced by DNA damage to repress cell cycle. RIPK2 activates NF-κB downstream of NOD2 (present in neighbor M4). CSF2 (GM-CSF) and CSF3 (G-CSF) are inflammatory cytokines. GBP2 is an interferon-gamma-induced GTPase. SQOR is involved in hydrogen sulfide metabolism. The module is significantly upregulated in CD inflammation. The combination of DNA damage sensing with innate immune cytokine production suggests a genotoxic stress-driven inflammatory program, potentially linked to NOD/RIPK2 innate immune signaling.
Genes
CSF2, CSF3, E2F7, GBP2, NBN, PLA1A, RIPK2, SELENOM, SQOR, TMEM120A
Most correlated modules
- Apoptosis Immune Regulation · correlation 0.89
- NF-κB Inflammatory Activation · correlation 0.82
- Hypoxia HIF Response · correlation 0.75
- Actin Cytoskeletal Dynamics · correlation 0.71
- Proteasome Assembly · correlation 0.66
- AhR mRNA Regulation · correlation 0.66
- Antigen Presentation IFN · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.