PARP14 — Poly(ADP-ribose) polymerase family member 14

PARP14 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PARP14's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Type I Interferon Anti-viral	GBP2, GBP4, IRF9, ISG15, ISG20, LY6E, MNDA, MX1 +9 more	View in SCUBA
CD4⁺ T cells	Interferon response Anti-viral	ACTN4, CAPZA1, CHMP4A, CHMP5, EFHD2, IL12RB1, LSP1, PIN1 +7 more	View in SCUBA
CD8⁺ T cells	Interferon-stimulated Genes Inflammation	ADAR, GBP1, OAS2, PARP9, RNF213, SAMD9, SAMD9L, SP110 +3 more	View in SCUBA
Endothelial	IFN-gamma Response Inflammation	APOL2, APOL6, BATF2, CARD16, CASP1, CD40, CXCL10, CXCL11 +18 more	View in SCUBA
Enterocytes	IFN-gamma response Inflammation	APOL6, BIRC3, GBP1, GBP2, IRF1, NUB1, PARP9, RNF213 +2 more	View in SCUBA
Fibroblasts	Type I Interferon Inflammatory	APOL6, BATF2, CXCL10, GBP1, IFI44L, IFIT2, IFIT3, ISG15 +6 more	View in SCUBA
Gamma-delta T cells	NK/T Cell Identity T cell maturation	AFTPH, ARHGAP17, ASXL2, ATF7IP, CALCOCO2, CD244, CLK3, GDI1 +24 more
Lymphatic endothelial	Antigen Presentation IFN Inflammation	ADAR, GPRC5B, HLA-F, KTN1, PTTG1IP, SCARB2, TAPBP, TMEM123 +2 more	View in SCUBA
Macrophages	Antiviral ISG Response Antiviral	ADAR, APOL6, ARID5A, CLEC7A, DDX60, DTX3L, EIF2AK2, ERICH1 +29 more	View in SCUBA
Monocytes	IFN-gamma Response Antiviral	APOL2, APOL6, CXCL10, ETV7, GBP1, GBP4, GBP5, IFIH1 +6 more	View in SCUBA
Mucosal-associated invariant T cell	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CAPG, CHORDC1, CSF1, DNAJA4, DNAJB4 +13 more

About the gene

Synonyms	ARTD8, BAL2, KIAA1268, pART8
Chromosome	3: 122680839-122730840
Predicted location	Intracellular
Essential gene	No
Protein class	Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Glycosyltransferase, Nucleotidyltransferase, Transferase
Biological process	Immunity, Innate immunity, Transcription, Transcription regulation

Function

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation. However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703'. Mono-ADP- ribosylates STAT6; enhancing STAT6-dependent transcription. In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation. Mono-ADP-ribosylates PARP9.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.