Heat Shock Response
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Stress |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
The top hub genes DNAJB1 (HSP40/DnaJ chaperone), HSP90AA1, HSP90AB1 (HSP90 isoforms), and HSPA8 (HSP70/constitutive) form a classic chaperone/heat shock protein network. UBB and UBC encode ubiquitin, which is co-regulated with HSPs during proteotoxic stress to facilitate protein degradation. RGS2 is induced by cellular stress and modulates G-protein signaling. ANKRD37 is a hypoxia-responsive gene. JUND (AP-1 family) can be activated by heat shock and oxidative stress. This is a tightly coherent heat shock/proteostasis module. Neighbor context: adjacent to M110 (dissociation stress) and M97 (activation stress), consistent with a proteostasis arm of the broader stress response in MAIT cells.
Genes
ANKRD37, DNAJB1, HSP90AA1, HSP90AB1, HSPA8, JUND, RGS2, UBB, UBC
Most correlated modules
- Dissociation Stress Response · correlation 0.86
- T cell Activation · correlation 0.83
- TCR-Induced Early Response · correlation 0.81
- Integrated Stress Response · correlation 0.79
- Splicing Regulation · correlation 0.76
- ER Stress UPR · correlation 0.75
- AP-1 Immediate Early · correlation 0.66
- Heat Shock Response · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.