Splicing Regulation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | RNA processing & translation |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence module contains CLK1 (CDC-like kinase that phosphorylates SR splicing factors), RBM39 (RNA binding/splicing factor), DDX24 (RNA helicase), and RSRC2 (arginine/serine-rich splicing coactivator), pointing to RNA splicing regulation. CCNH (cyclin H) activates CDK7 involved in transcription and DNA repair. NFAT5 is an osmotic stress-responsive transcription factor. TSPYL2 regulates chromatin. PIK3AP1 and ARHGAP9 contribute signaling/cytoskeletal elements. PTPN7 is a hematopoietic phosphatase. IL23R is expressed on MAIT cells and links to Tc17 biology but shows weak membership. AZIN1 (antizyme inhibitor) regulates polyamine synthesis. AREG (amphiregulin) is a tissue repair/regulatory cytokine. The module appears to reflect a stress-associated RNA processing and splicing regulatory program. CLK1-RBM39-DDX24-RSRC2 form a splicing kinase axis. Neighbor context: adjacent to M110 (splicing factors SRSF7/SRSF3), further supporting splicing regulation as a shared theme.
Genes
AREG, ARHGAP9, AZIN1, CCNH, CLK1, DDX24, DNAJB6, IL23R, NEU1, NFAT5, PIK3AP1, PTPN7, RBM39, RLIM, RRP12, RSRC2, TSPYL2, ZBTB21
Most correlated modules
- Rho GTPase Migration · correlation 0.83
- T cell Activation · correlation 0.82
- RNA Processing Stress · correlation 0.80
- Tissue Residency Regulation · correlation 0.80
- NF-κB RNA Regulation · correlation 0.80
- cAMP Immune Regulation · correlation 0.80
- NF-κB Survival Signaling · correlation 0.79
- NF-κB Activation · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.