ER Stress UPR
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Stress |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes DDIT3, HERPUD1, and DNAJB9 are canonical ER stress/UPR markers. MAP1LC3B indicates autophagy activation downstream of ER stress. SELENOK is an ER membrane selenoprotein. LDHA reflects metabolic reprogramming under stress. EIF4A1 and RBM8A contribute to translational regulation during UPR. This is a coherent ER stress and Unfolded Protein Response module.
Genes
DDIT3, DNAJB9, EIF4A1, GTF2B, HERPUD1, HNRNPA0, IDI1, LDHA, MAP1LC3B, MIDN, NXT1, PTMA, RBM8A, SAP18, SELENOK, SKIL, STK17B, SUB1
Most correlated modules
- Dissociation Stress Response · correlation 0.86
- NF-κB Negative Feedback · correlation 0.86
- NF-κB Activation · correlation 0.84
- Integrated Stress Response · correlation 0.84
- RNA Splicing m6A · correlation 0.83
- BMP/TGF-β Inhibitory · correlation 0.82
- RNA Processing Stress · correlation 0.80
- Stress-Induced Growth Arrest · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.