UBB — Ubiquitin B
UBB belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Early Response Stress Stress | ANKRD37, DNAJA1, GTF2B, NR4A2, SAT1, SIK1, SOCS3, UBC | View in SCUBA |
| CD4⁺ T cells | Heat Shock Response Stress | ANKRD37, CHORDC1, DEDD2, DNAJA1, DNAJA4, DNAJB1, DNAJB4, HSP90AA1 +12 more | View in SCUBA |
| CD8⁺ T cells | Vesicle Trafficking Protein processing & ER | AP2M1, ARF1, CDC37, EWSR1, GHITM, GNB2, LMAN2, PPP2CA +1 more | View in SCUBA |
| Fibroblasts | Fibroblast Quiescence Housekeeping | BTG1, EIF1, EIF4A2, FNIP1, ID2, KLF2, KLF4, RHOB +5 more | View in SCUBA |
| Gamma-delta T cells | Anabolic Activation Response Housekeeping | ABHD5, ATF4, ATP6V0C, ATP6V1G1, BCL7B, BUD31, CALM2, CHRAC1 +26 more | |
| Goblet cells | Basal Transcription Housekeeping | ACTB, ACTG1, CALM2, DYNLL1, ELOC, ENY2, GTF2A2, LSM8 +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | Heat Shock Response Stress | ANKRD37, DNAJB1, HSP90AA1, HSP90AB1, HSPA8, JUND, RGS2, UBC |
About the gene
| Synonyms | FLJ25987, MGC8385 |
|---|---|
| Chromosome | 17: 16380798-16382745 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell- cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.