Integrated Stress Response
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Stress |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 16 genes have a known function matching the annotation |
Why this annotation
ATF4 is the master transcription factor of the integrated stress response (ISR). ODC1 (ornithine decarboxylase) drives polyamine biosynthesis downstream of mTOR/anabolic signaling. EIF4A3 and EIF5 regulate translation initiation, consistent with ISR-mediated translational reprogramming. SGK1 is a PI3K/mTOR-regulated survival kinase. UBE2S functions in ubiquitin-mediated protein degradation under stress. SERTAD1 is induced by mitogenic/stress signals. SRSF2/5 mediate stress-coupled splicing changes. IFRD1 modulates transcription factor activity under stress. MKNK2 phosphorylates eIF4E linking MAPK stress to translation. This is a coherent ISR/anabolic stress-response module.
Genes
ATF4, EIF4A3, EIF5, FAM53C, IFRD1, MARCKSL1, MKNK2, ODC1, PLK2, SERTAD1, SGK1, SRSF2, SRSF5, TUBB4B, UBE2S, ZFAND5
Most correlated modules
- NF-κB Negative Feedback · correlation 0.90
- Dissociation Stress Response · correlation 0.89
- T cell Activation · correlation 0.85
- RNA Processing Stress · correlation 0.85
- BMP/TGF-β Inhibitory · correlation 0.84
- ER Stress UPR · correlation 0.84
- Stress-Induced Growth Arrest · correlation 0.84
- mRNA Decay Program · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.