Chromatin Epigenetic Regulation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
This module contains a diverse set of broadly expressed genes with uniform distribution across subsets and low mean expression (0.320, ~27% positive). Hub genes include TAB2 (TGF-beta/NF-kB signaling adaptor), UBE3A (E3 ubiquitin ligase), MDM4 (p53 regulator), KAT6B (histone acetyltransferase), ZMYND11 (chromatin reader/transcriptional repressor), PCGF5 (Polycomb group), and TRAPPC10 (trafficking). ADD1 is a cytoskeletal protein (adducin), TENT2 is a poly(A) polymerase, and PACS1 is involved in protein sorting. The module does not converge on a single crisp biological program but leans toward chromatin/epigenetic regulation and ubiquitin-mediated protein quality control. ANKRD36/ANKRD36C are poorly characterized. The overall picture is a loosely coupled housekeeping/regulatory gene set with chromatin regulatory flavor. Given the mix of chromatin modifiers (KAT6B, ZMYND11, PCGF5), ubiquitin pathway (UBE3A), and signaling adaptors (TAB2, MDM4), this most resembles a general chromatin/epigenetic regulatory program active at baseline.
Genes
ADD1, ANKRD36, ANKRD36C, CHIC2, ERICH1, ESYT2, KAT6B, MDM4, PACS1, PCGF5, TAB2, TENT2, TRAPPC10, UBE3A, ZMYND11, ZNF652
Most correlated modules
- Epigenetic Maintenance · correlation 0.92
- TGF-β Immune Regulation · correlation 0.91
- Histone Modification · correlation 0.86
- Chromatin Remodeling · correlation 0.85
- RNA Splicing Processing · correlation 0.83
- Lymphocyte Survival · correlation 0.82
- Tissue Residency · correlation 0.81
- Chromatin & Splicing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.