PACS1 — Phosphofurin acidic cluster sorting protein 1
PACS1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PACS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T Cell Migration migration & adhesion | BCL2, BPNT2, CCDC88B, DNM2, EDC4, GMDS, LRRC58, MARK3 +14 more | |
| Mucosal-associated invariant T cell | Chromatin Epigenetic Regulation DNA/chromatin regulation | ADD1, ANKRD36, ANKRD36C, CHIC2, ERICH1, ESYT2, KAT6B, MDM4 +7 more | |
| Neutrophils | ER Stress Response Stress | ATF6, DISC1, GRB10, KIAA0825, MAP2K4, NCOA1, TMCC1 |
About the gene
| Synonyms | FLJ10209, KIAA1175 |
|---|---|
| Chromosome | 11: 66070272-66244744 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Host-virus interaction |
Function
Coat protein that is involved in the localization of trans- Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster- containing cytoplasmic domain of these molecules with the adapter- protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.