RNA Splicing Processing
Gene co-expression module in Mucosal-associated invariant T cell
| Category | RNA processing & translation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
SRSF1 is a canonical serine/arginine-rich splicing factor; TIA1 is an RNA-binding protein regulating alternative splicing and stress granule assembly; SCAF11 is a splicing-associated factor. EIF3A is the largest subunit of eIF3, a central translation initiation complex. SEC24C encodes a COPII coat component linking ER export to translational programs. KDM5A is a histone demethylase that can regulate co-transcriptional splicing. GAB3 is an immune signaling adapter. The module is centered on post-transcriptional RNA processing with a translation initiation component, consistent with a program regulating mRNA fate in MAIT cells.
Genes
CCDC88B, EHBP1L1, EIF3A, GAB3, KDM5A, KIDINS220, LIX1L, PCSK7, SCAF11, SEC24C, SRSF1, TIA1, USP34
Most correlated modules
- Vesicle Membrane Trafficking · correlation 0.91
- Chromatin Remodeling · correlation 0.90
- Epigenetic Maintenance · correlation 0.88
- TGF-β Immune Regulation · correlation 0.87
- Chromatin Remodeling · correlation 0.87
- Chromatin & Splicing · correlation 0.85
- Lymphocyte Survival · correlation 0.85
- Histone Modification · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.