Chromatin Remodeling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
RIF1 is a major regulator of DNA replication timing, DNA double-strand break repair, and chromatin organization. SUPT16H encodes the large subunit of the FACT (facilitates chromatin transcription) complex, a chromatin remodeler that reorganizes nucleosomes during transcription and replication. BAZ2B contains a bromodomain and is involved in chromatin remodeling. CD2AP is a T cell-specific adapter linking surface receptors to the actin cytoskeleton. SPAG9 (JIP4) is a scaffold for MAP kinases. TRIM44 is a ubiquitin-like domain E3 ligase. The module is anchored by DNA/chromatin regulatory programs with accessory T cell signaling components.
Genes
BAZ2B, C1RL, CD2AP, GIT2, KIF5B, MIA2, RIF1, SPAG9, SUPT16H, TRIM44
Most correlated modules
- Epigenetic Maintenance · correlation 0.90
- Histone Modification · correlation 0.90
- Vesicle Membrane Trafficking · correlation 0.88
- Lymphocyte Survival · correlation 0.87
- RNA Splicing Processing · correlation 0.87
- Chromatin Epigenetic Regulation · correlation 0.85
- TGF-β Immune Regulation · correlation 0.83
- Tissue Residency · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.