Tissue Residency
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Tissue residence |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include HES4 (Notch target, lymphocyte development), MALT1 (NF-kB signaling, lymphocyte activation), IRF8 (transcription factor critical for lymphoid/myeloid differentiation), ITGAE (CD103, tissue residency integrin), ACSL1 (long-chain fatty acid metabolism, inflammatory macrophage polarization), SKI (TGF-beta co-repressor), STAM (endosomal signaling, JAK-STAT pathway), and SYNJ2 (phosphoinositide phosphatase, membrane trafficking). ITGAE/CD103 is a canonical tissue-resident marker for T cells and is particularly relevant for MAIT cells in mucosal/tissue compartments. IRF8 is involved in innate immune transcriptional programs. MALT1 links to TCR-NF-kB signaling. HES4 and SKI suggest active Notch/TGF-beta regulatory input. Overall, the combination of ITGAE, IRF8, MALT1, HES4, and membrane trafficking genes points to a tissue-residency and differentiation/activation program in MAIT cells, consistent with tissue-homing and residency establishment.
Genes
ACSL1, AMFR, CRACDL, DHX36, HES4, IRF8, ITGAE, LZTFL1, MACO1, MALT1, RAPGEF2, RNF145, SKI, STAM, SYNJ2, TBC1D2B, USP16
Most correlated modules
- Metabolic Homeostasis · correlation 0.93
- NF-κB Survival Signaling · correlation 0.85
- Epigenetic Maintenance · correlation 0.84
- Rho GTPase Migration · correlation 0.83
- Tissue Residency Regulation · correlation 0.81
- Chromatin Epigenetic Regulation · correlation 0.81
- Chromatin Remodeling · correlation 0.78
- Vesicle Membrane Trafficking · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.