Mitochondrial OxPhos
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
This is a tightly coherent (core) module with strong convergence on mitochondrial and oxidative phosphorylation functions. Hub genes: MDH1 (malate dehydrogenase, TCA cycle), PARK7 (DJ-1, mitochondrial stress/redox sensor), CDK2AP2 (cell cycle/DNA repair accessory), PSMA5 (proteasome subunit alpha), COX7A2L (cytochrome c oxidase subunit, complex IV), ATP5PD (ATP synthase subunit, complex V), CD63 (lysosomal/multivesicular body marker), MESD (ER chaperone for Wnt receptors), MRPS18C (mitochondrial ribosome small subunit), NDUFS2 (NADH dehydrogenase subunit, complex I), ZNHIT1 (chromatin remodeling), NDUFS8 (complex I), MRPS31 (mitochondrial ribosome), VPS72 (chromatin/vacuolar). The strong presence of NDUFS2, NDUFS8, COX7A2L, ATP5PD, MDH1, MRPS18C, MRPS31 clearly defines a mitochondrial OxPhos/respiration program. PARK7 adds mitochondrial stress context. The module is uniformly expressed, consistent with housekeeping-level mitochondrial activity in all MAIT cells.
Genes
ATP5PD, CD63, CDK2AP2, COX7A2L, MDH1, MESD, MRPS18C, MRPS31, NDUFS2, NDUFS8, PARK7, PSMA5, VPS72, ZNHIT1
Most correlated modules
- Cellular Housekeeping · correlation 0.95
- Oxidative Stress Response · correlation 0.94
- Cellular Housekeeping · correlation 0.94
- Type I Interferon · correlation 0.92
- Mitochondrial Ribosome · correlation 0.91
- RNA Biogenesis & Folding · correlation 0.90
- Mitochondrial Metabolism & Redox · correlation 0.88
- Lymphocyte Trafficking · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.