MESD — Mesoderm development LRP chaperone
MESD belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MESD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cellular biosynthesis Housekeeping | CCDC32, CTSB, HDGF, MEA1, MFSD6, MRPS11, MTHFD2, NAA60 +9 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ANKRD13D, ATP5ME, ATP5MJ, CAMTA1, CD2, CTDNEP1, DPP7, EIF3D +11 more | |
| Innate lymphoid cells | Mitochondrial Translation Mitochondrial & OxPhos | ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7 +37 more | View in SCUBA |
| Macrophages | ER Protein Processing Housekeeping | ACTR1A, ANXA7, ATP6AP1, ATP6AP2, ATP6V0B, ATP6V0E1, AUP1, BCAP31 +41 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial OxPhos Mitochondrial & OxPhos | ATP5PD, CD63, CDK2AP2, COX7A2L, MDH1, MRPS18C, MRPS31, NDUFS2 +5 more |
About the gene
| Synonyms | BOCA, KIAA0081, MESDC2 |
|---|---|
| Chromosome | 15: 80946289-80989828 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Chaperone |
| Biological process | Wnt signaling pathway |
Function
Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.