Cellular Housekeeping
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Housekeeping |
|---|---|
| Genes | 26 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 16 of 26 genes have a known function matching the annotation |
Why this annotation
This module contains a diverse set of housekeeping genes expressed uniformly across all subsets. Hub genes include MEAF6 (chromatin/SAGA complex), TMEM230 (membrane trafficking), GSTO1 (glutathione transferase/oxidative stress defense), APOBEC3C (DNA editing), PRDX2 (peroxiredoxin, antioxidant), NMT1 (N-myristoyltransferase), AP1M1 (clathrin adaptor), DBNL (actin cytoskeleton), GZMA (granzyme A, cytotoxic), APEX1 (DNA repair), ENO1 (glycolysis), PDIA4 (ER protein folding), ANP32A (chromatin/transcription), ANXA5 (annexin), DCK (nucleoside kinase). The uniform expression and broad functional diversity suggest a general housekeeping/maintenance program rather than a specific effector program. GZMA is notable as a cytotoxic marker for MAITs but its membership is moderate and the overall module is dominated by housekeeping functions. The module likely reflects basal cellular maintenance processes across all MAIT cells.
Genes
AKR7A2, ANP32A, ANXA5, AP1M1, APEX1, APOBEC3C, CDC26, DBNL, DCK, ENO1, GSTO1, GZMA, LMO4, MEAF6, MITD1, NHP2, NMT1, PDCD5, PDIA4, PDIA6, PRDX2, SLC38A10, SNX6, SPRYD3, TMEM230, VASP
Most correlated modules
- Mitochondrial OxPhos · correlation 0.95
- Oxidative Stress Response · correlation 0.94
- Cellular Housekeeping · correlation 0.92
- RNA Biogenesis & Folding · correlation 0.92
- Type I Interferon · correlation 0.91
- Lymphocyte Trafficking · correlation 0.89
- Mitochondrial Ribosome · correlation 0.88
- ER Protein Glycosylation · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.