RNA Biogenesis & Folding
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Housekeeping |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include PA2G4 (ribosome biogenesis/EBP1), CCT3 (chaperonin complex), LSM4 (snRNA/splicing), POLR2E (RNA Pol II subunit), FKBP1A/FKBP8 (FK506-binding protein folding), MAT2B (methionine metabolism), and CTDSP1 (CTD phosphatase involved in RNA Pol II regulation). Together these form a housekeeping program spanning RNA biogenesis, splicing, and protein folding. Uniform expression across all subsets and moderate detection support a constitutive housekeeping role. Neighbor context: sits among broader housekeeping/metabolic modules, consistent with general cellular maintenance.
Genes
ADH5, CCT3, CTDSP1, FAM117A, FKBP1A, FKBP8, LSM4, MAT2B, MFSD10, NDUFC1, NT5C, PA2G4, POLR2E, RNF181, SCP2
Most correlated modules
- Cellular Housekeeping · correlation 0.92
- Lymphocyte Trafficking · correlation 0.91
- Mitochondrial OxPhos · correlation 0.90
- Mitochondrial Metabolism & Redox · correlation 0.89
- Mitochondrial Ribosome · correlation 0.88
- Immunoproteasome Activity · correlation 0.88
- Cellular Housekeeping · correlation 0.88
- Type I Interferon · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.