Lymphocyte Trafficking
Gene co-expression module in Mucosal-associated invariant T cell
| Category | migration & adhesion |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes: SH3BP5 (SH3 binding protein, JNK/SAPK signaling), TES (tessin, focal adhesion/actin), SELPLG (PSGL-1, selectin ligand, lymphocyte homing/adhesion), YWHAB (14-3-3 beta, signaling scaffold), PTP4A2 (protein tyrosine phosphatase), BIN1 (amphiphysin, membrane tubulation), RAB29 (vesicle trafficking/Golgi), THEM4 (CTMP, Akt signaling), DGKZ (diacylglycerol kinase, signaling), ANXA2 (annexin A2, membrane/cytoskeletal), ARL14EP (ADP-ribosylation factor effector), SEC11A (signal peptidase), SET (PP2A inhibitor/chromatin), BTN3A2 (butyrophilin, MAIT/gamma-delta T cell antigen presentation). SELPLG is a key lymphocyte trafficking molecule, TES and ANXA2 link to cytoskeletal/adhesion, BIN1 to membrane dynamics, RAB29 to vesicle trafficking. Together these genes suggest a migration, adhesion, and membrane trafficking program. SELPLG (PSGL-1) as a core hub strongly supports a lymphocyte trafficking/homing identity.
Genes
AASDHPPT, ANXA2, ARL14EP, ATP2A3, BIN1, BTN3A2, DGKZ, OSTC, PTP4A2, RAB29, SEC11A, SELPLG, SET, SH3BP5, TES, THEM4, YWHAB
Most correlated modules
- RNA Biogenesis & Folding · correlation 0.91
- Cellular Housekeeping · correlation 0.89
- Antigen Processing · correlation 0.85
- Mitochondrial Metabolism & Redox · correlation 0.85
- Mitochondrial OxPhos · correlation 0.84
- Cyclophilin-Mediated Folding · correlation 0.84
- Type I Interferon · correlation 0.83
- Immunoproteasome Activity · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.