Type I Interferon
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Inflammation |
|---|---|
| Genes | 15 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
This module has strong coherence and is enriched for interferon-stimulated genes (ISGs) and antiviral defense factors. Hub genes: ABCF2 (ABC transporter, antiviral), SHFL (shuffle/C19orf66, broad antiviral restriction factor), PSMB8 (proteasome beta-8/LMP7, IFN-gamma inducible, antigen processing), UBE2L6 (ISG15 E2 conjugating enzyme), PARP10 (mono-ADP-ribosylation, antiviral), CHST12 (sulfotransferase), BST2 (tetherin, IFN-inducible antiviral), LY6E (IFN-stimulated gene, antiviral), PSME2 (proteasome activator PA28-beta, IFN-inducible), ACAA2 (fatty acid beta-oxidation), ANXA2R (annexin A2 receptor), NDUFC2 (complex I subunit), IRF9 (interferon regulatory factor 9, ISGF3 component), TRIM69 (tripartite motif, antiviral), LYSMD2 (lysM domain). The strong ISG signature — SHFL, PSMB8, UBE2L6, BST2, LY6E, PSME2, IRF9, TRIM69, PARP10 — clearly defines a type I/II interferon response program. This is consistent with an antiviral/interferon-stimulated gene module in MAITs.
Genes
ABCF2, ACAA2, ANXA2R, BST2, CHST12, IRF9, LY6E, LYSMD2, NDUFC2, PARP10, PSMB8, PSME2, SHFL, TRIM69, UBE2L6
Most correlated modules
- Mitochondrial OxPhos · correlation 0.92
- Cellular Housekeeping · correlation 0.91
- Cellular Housekeeping · correlation 0.87
- RNA Biogenesis & Folding · correlation 0.87
- Oxidative Stress Response · correlation 0.87
- Mitochondrial Metabolism & Redox · correlation 0.84
- Lymphocyte Trafficking · correlation 0.83
- Type I Interferon · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.