Mitochondrial Ribosome
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 31 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 31 genes have a known function matching the annotation |
Why this annotation
This module has strong representation of mitochondrial ribosomal proteins (MRPS34, MRPL14, MRPL51), mitochondrial complex I subunit (NDUFS6), mitochondrial peroxiredoxin (PRDX3), mitochondrial lipid transfer (PRELID1), and related small metabolic/housekeeping genes (MGST3 - mitochondrial glutathione transferase, DCTPP1 - nucleotide metabolism, LSM10 - snRNA processing, CNPY2 - ER chaperone). SNAPIN links to lysosomal/SNARE function. ILK (integrin-linked kinase) and RAB10 (vesicle trafficking) are peripheral members. The core identity is mitochondrial ribosomal/respiratory chain housekeeping, which fits a basal metabolic program broadly expressed across MAIT cell states (uniform expression, ~26% detection). RECQL (DNA helicase) and TMEM genes are less diagnostic. The neighboring modules (M88 trafficking, M86 stress) suggest this batch captures baseline cell maintenance programs.
Genes
AGTRAP, BRK1, C11orf68, C14orf119, CNPY2, CZIB, DCTPP1, DYNC1I2, FOXN2, ILK, IPCEF1, LARS1, LSM10, METTL26, MGST3, MRPL14, MRPL51, MRPS34, NDUFS6, PHPT1, PRDX3, PRELID1, PREPL, RAB10, RECQL, SNAPIN, SRP9, STX10, TMEM179B, TMEM219, UPF2
Most correlated modules
- Mitochondrial OxPhos · correlation 0.91
- Oxidative Stress Response · correlation 0.91
- Cellular Housekeeping · correlation 0.88
- RNA Biogenesis & Folding · correlation 0.88
- Cellular Housekeeping · correlation 0.87
- Immunoproteasome Activity · correlation 0.83
- Type I Interferon · correlation 0.82
- Vesicle Membrane Trafficking · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.