Cellular Housekeeping
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Housekeeping |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
Top hub genes include TPI1 (triose-phosphate isomerase, glycolysis), AP2M1 (clathrin-mediated endocytosis adaptor), RNASEH2C (RNA-DNA hybrid processing), SSBP4 (single-strand DNA binding), CD2 (T cell surface marker), TRMT112 (tRNA methyltransferase), DYNLL1 (dynein light chain), RNF187 (E3 ubiquitin ligase), YWHAH (14-3-3 eta, signaling scaffold), ABI3 (actin/signaling), CKLF (chemokine-like factor), POLR2L (RNA pol II), FDFT1 (cholesterol biosynthesis), LRP10 (LDL receptor), CD151 (tetraspanin), NOP10 (ribosome biogenesis). The module is heterogeneous — it combines glycolytic, endocytic, RNA processing, and surface marker genes. Uniform expression across all subsets and moderate coherence of several genes suggest a basal housekeeping program with mixed components. The neighbor context (near M8, M10) supports a general housekeeping interpretation. The mixture of metabolic, signaling, and surface genes without a dominant pathway makes this a general housekeeping module.
Genes
ABI3, AP2M1, CD151, CD2, CKLF, DYNLL1, FDFT1, LRP10, NOP10, POLR2L, RNASEH2C, RNF187, SSBP4, TPI1, TRMT112, YWHAH
Most correlated modules
- Mitochondrial OxPhos · correlation 0.94
- Cellular Housekeeping · correlation 0.92
- Oxidative Stress Response · correlation 0.90
- RNA Biogenesis & Folding · correlation 0.88
- Mitochondrial Ribosome · correlation 0.87
- Type I Interferon · correlation 0.87
- Mitochondrial Metabolism & Redox · correlation 0.84
- ER Stress Response · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.