Mitochondrial Metabolism & Redox
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include SSBP1 (mitochondrial single-stranded DNA binding protein), PYCR2 (mitochondrial proline biosynthesis), EGLN2 (PHD1 prolyl hydroxylase — oxygen/HIF sensing), HMOX2 (heme oxygenase 2 — heme catabolism, redox), DAD1 (defender against apoptosis/glycosylation), ATP5PF (ATP synthase), SDHD (Complex II), UQCRQ (Complex III), NDUFS7 (Complex I), MRPS21 (mitoribosome). The module centers on mitochondrial metabolism and biogenesis with an oxygen/redox sensing component (EGLN2, HMOX2). Neighbor context: flanked by M103 and M104 which are also OxPhos-heavy, indicating a cluster of mitochondrial housekeeping modules; this one has the strongest oxygen-sensing flavor.
Genes
ATP5PF, CHURC1, DAD1, DHRS7, EGLN2, HMOX2, ITM2B, MRPS21, NDUFS7, PEBP1, PYCR2, RALBP1, SDHD, SSBP1, UBL5, UQCRQ
Most correlated modules
- RNA Biogenesis & Folding · correlation 0.89
- Immunoproteasome Activity · correlation 0.89
- Mitochondrial OxPhos · correlation 0.88
- ER Glycosylation & Ubiquitin · correlation 0.88
- Lymphocyte Trafficking · correlation 0.85
- Type I Interferon · correlation 0.84
- Cellular Housekeeping · correlation 0.84
- Antigen Processing · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.