SCUBA

SCAF11 — SR-related CTD associated factor 11

SCAF11 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SCAF11's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsB-cell signaling regulators
BCR/AP1/NFKb pathway
AKNA, ATF7IP, DNAJB14, FCHSD2, GOLGA4, IKZF3, INPP5D, MYCBP2 +3 moreView in SCUBA
CD4⁺ T cellsTranscription/RNA processing
RNA processing
ANKRD17, BDP1, CCDC97, CDK13, CHIC2, CLK4, CNOT6L, CRNKL1 +29 moreView in SCUBA
Gamma-delta T cellsActin Cytoskeletal Regulation
Cytoskeletal
ACTR2, AP3B1, AP3M1, AZI2, CAPZA1, CEP250, CPSF3, DIDO1 +25 more
Glial cellsGlial Neural Scaffolding
Cytoskeletal
AKAP6, ARHGAP24, COL5A3, EIF4G2, NFIX, PPP1R12B, SEMA6D, USP53View in SCUBA
Innate lymphoid cellsGolgi RNA Processing
RNA processing & translation
ANKRD12, ATM, DDX17, GCC2, GOLGA4, LUC7L3, MIER1, MLEC +11 moreView in SCUBA
Lymphatic endothelialActomyosin Contractility
Cytoskeletal
AFAP1L1, C1orf21, COBLL1, EEA1, GNB1, MAP4, OSBPL8, PPP1R12A +6 moreView in SCUBA
MacrophagesRNA Processing Housekeeping
Housekeeping
BAZ1A, BDP1, CCAR1, CCDC88A, CLIP1, CUL5, DHX36, DNM1L +32 moreView in SCUBA
Mucosal-associated invariant T cellRNA Splicing Processing
RNA processing & translation
CCDC88B, EHBP1L1, EIF3A, GAB3, KDM5A, KIDINS220, LIX1L, PCSK7 +4 more
Smooth muscle cellsKLF6/ZNF24 regulators
Activation
ACSL3, ARHGAP1, CTBP2, KLF6, PLEKHA4, TNFAIP8L3, ZNF24View in SCUBA

About the gene

SynonymsCASP11, SFRS2IP, SIP1, SRRP129, SRSF2IP
Chromosome12: 45919131-45992120
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classPredicted intracellular proteins, Predicted membrane proteins
Biological processmRNA processing, mRNA splicing

Function

Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.