Glycolytic Metabolism
Gene co-expression module in Natural Killer cells
| Category | Metabolism |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Top hub genes ENO1, GAPDH, TPI1 are core glycolytic enzymes. COX5A is a mitochondrial complex IV subunit. YBX1 is a multifunctional RNA/DNA binding protein involved in stress granules and translation. SET inhibits PP2A and is involved in chromatin. SNRPB is a spliceosomal protein. MZT2A/MZT2B are components of the gamma-TuRC microtubule nucleation complex. PRKDC (DNA-PK) and PARP1 are DNA repair enzymes. The module combines glycolysis with housekeeping functions. The glycolytic triad (ENO1/GAPDH/TPI1) is the strongest coherent signal, suggesting a glycolytic metabolic program as the core, with peripheral housekeeping genes.
Genes
COX5A, ENO1, GAPDH, MZT2A, MZT2B, PARP1, PRKDC, SET, SNRPB, TPI1, YBX1
Most correlated modules
- Oxidative Stress Response · correlation 0.89
- Chromatin Remodeling · correlation 0.87
- Energy Metabolism · correlation 0.83
- Immunoproteasome Activation · correlation 0.82
- hnRNP RNA Processing · correlation 0.82
- Actin Cytoskeleton Remodeling · correlation 0.79
- G2/M Transition · correlation 0.75
- NK Cell Activation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.