SCUBA

NUCKS1 — Nuclear casein kinase and cyclin dependent kinase substrate 1

NUCKS1 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NUCKS1's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsChromatin Remodeling
DNA/chromatin regulation
ANP32B, ATP5IF1, CALM3, CBX3, COMMD4, HAT1, HMGA1, HMGB1 +9 moreView in SCUBA
CD8⁺ T cellsS-phase Chromatin Replication
Cell cycle
ANP32E, BRCA2, CKAP2, HDGF, HP1BP3, LBR, MIS18BP1, NSD2 +4 moreView in SCUBA
EndothelialNuclear Transport
Housekeeping
AAMDC, ANP32B, CBX5, CDK4, CKAP4, COMMD4, COQ2, CSE1L +18 moreView in SCUBA
FibroblastsMicrofibril ECM Fibroblast
ECM production
CD302, CD81, COX7C, CYBRD1, EPHX1, MFAP4, NFIX, NOP53 +2 moreView in SCUBA
Gamma-delta T cellsTranscriptional Elongation Control
DNA/chromatin regulation
ANP32B, AP2M1, ARF5, AURKAIP1, CCDC124, CUEDC2, CYC1, DCTN3 +19 more
Glial cellsGlial Homeostatic Identity
Development
GAS7, QKI, SEMA3C, SIPA1L2, SORCS1, TMEM245, VCL, ZBTB20View in SCUBA
Innate lymphoid cellsMitochondrial Translation
Mitochondrial & OxPhos
ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7 +37 moreView in SCUBA
Lymphatic endothelialIntegrin Focal Adhesion
migration & adhesion
APLP2, ATP5F1A, ATP5PB, DEK, ITGB1, LIMS1, MCFD2, NPC2 +4 moreView in SCUBA
MacrophagesDNA Replication Metabolism
Cell cycle
AGPAT5, CBX1, DCK, FADS1, HACD3, HADH, ICMT, IDH2 +11 moreView in SCUBA
MonocytesBiosynthetic Metabolic Activation
Housekeeping
AHCY, EEF1B2, IMPDH2, NME1, NPM1, PABPC4, PEBP1, PRDX4 +4 moreView in SCUBA
Natural Killer cellsChromatin Remodeling
DNA regulation & transcription
ANP32E, CALM3, CBX5, COX8A, DEK, HMGB1, NUCB2, PSIP1 +1 moreView in SCUBA
NeutrophilsMitotic Spindle
Cell cycle
ANP32B, ANP32E, DEK, H2AZ2, H4C3, HMGB1, HNRNPH1, HP1BP3 +4 more
Smooth muscle cellsProliferative Biosynthesis
Housekeeping
ARF5, BUB3, CBX5, DCTN3, DUT, HMGN2, IDH2, KRTCAP2 +7 moreView in SCUBA

About the gene

SynonymsNUCKS
Chromosome1: 205712822-205750182
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins
Biological processDNA damage, DNA repair

Function

Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D- loop structures, but with less affinity than RAD51AP1

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.