Immunoproteasome Activation
Gene co-expression module in Natural Killer cells
| Category | Inflammation |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Five of nine genes are proteasome subunits: PSMB3, PSMB8, PSMB9 (immunoproteasome catalytic subunits, IFN-γ inducible), PSME1, PSME2 (PA28 activator complex, immunoproteasome activator). PPIA (cyclophilin A, protein folding/immune signaling), PDIA6 (ER oxidoreductase/protein folding), LDHB (metabolic), EIF5A (translation). The dominance of immunoproteasome subunits (PSMB8/PSMB9 are IFN-γ-inducible β1i/β5i) and PA28 activators strongly indicates an immunoproteasome/antigen processing program. Significant upregulation in both UC and CD inflammation is consistent with IFN-γ-driven immunoproteasome induction.
Genes
EIF5A, LDHB, PDIA6, PPIA, PSMB3, PSMB8, PSMB9, PSME1, PSME2
Most correlated modules
- Glycolytic Metabolism · correlation 0.82
- Oxidative Stress Response · correlation 0.81
- Actin Cytoskeleton Remodeling · correlation 0.81
- Chromatin Remodeling · correlation 0.78
- Energy Metabolism · correlation 0.78
- NK Cytotoxic Activation · correlation 0.75
- hnRNP RNA Processing · correlation 0.75
- NK Cell Activation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.