SMC1A — Structural maintenance of chromosomes 1A
SMC1A belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMC1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Epigenetic Chromatin Maintenance DNA/chromatin regulation | BAZ1B, DDX46, DNMT1, HNRNPAB, NASP, NOP56, SET, SMC3 +2 more | View in SCUBA |
| Endothelial | Nuclear Transport Housekeeping | AAMDC, ANP32B, CBX5, CDK4, CKAP4, COMMD4, COQ2, CSE1L +18 more | View in SCUBA |
| Gamma-delta T cells | Mitotic Spindle Cell cycle | CAPRIN1, CDK5RAP2, CKAP5, CNTRL, DEK, DNMT1, FAM111A, GMPS +11 more | |
| Goblet cells | Chromatin Remodeling Repair chromatin regulation & transcription | CBX5, HACD3, NAP1L1, PARP1, PPM1G, PRKDC, PSIP1, SMC3 +1 more | View in SCUBA |
| Macrophages | Replication Chromatin Assembly Cell cycle | ANP32B, CBX3, CDK4, COPS3, DEK, DNMT1, EMC8, EXOSC8 +22 more | View in SCUBA |
| Mucosal-associated invariant T cell | Endosomal Actin Organization Cytoskeletal | ARHGEF2, ATF6B, CGGBP1, FUT11, IARS2, ICE2, INPP5B, SH3BP2 +7 more | |
| Natural Killer cells | Chromatin Remodeling DNA regulation & transcription | ANP32E, CALM3, CBX5, COX8A, DEK, HMGB1, NUCB2, NUCKS1 +1 more | View in SCUBA |
About the gene
| Synonyms | DXS423E, KIAA0178, SB1.8, SMC1L1, Smcb |
|---|---|
| Chromosome | X: 53374149-53422728 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, DNA damage, DNA repair, Meiosis, Mitosis |
Function
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.