Oxidative Stress Response
Gene co-expression module in Natural Killer cells
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
Hub gene TXN (thioredoxin) anchors a redox/stress response. Supporting genes include CCT6A (chaperonin complex), HINT1 (nucleotide hydrolase), RANBP1 (RAN-binding, nuclear transport), BANF1 (nuclear envelope integrity), HMGN1 (chromatin remodeling under stress), NPM1 (nucleolar stress sensor), PA2G4 (translational stress response), HNRNPF (RNA processing), CHCHD2 (mitochondrial stress). The combination of redox (TXN), chaperone (CCT6A), and nuclear stress sensors (NPM1, BANF1) points to a general proteostatic/oxidative stress response. Upregulated in CD inflammation supports in vivo relevance.
Genes
BANF1, CCDC167, CCT6A, CHCHD2, HINT1, HMGN1, HNRNPF, NPM1, PA2G4, RANBP1, TXN
Most correlated modules
- Glycolytic Metabolism · correlation 0.89
- hnRNP RNA Processing · correlation 0.89
- Actin Cytoskeleton Remodeling · correlation 0.87
- Immunoproteasome Activation · correlation 0.81
- Metabolic Activation · correlation 0.81
- Chromatin Remodeling · correlation 0.77
- Cellular Homeostasis · correlation 0.75
- S/G2M Cell Cycle · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.